The Archduchess Margaret (Margaretha) of Austria (10 January 1480 – 1 December 1530) was a Habsburg princess, the daughter of Maximilian I, Holy Roman Emperor and Mary of Burgundy. Archduchess Margaret as Duchess of Savoy, 15th century, Margarete von Österreich als Herzogin von Savoyen

In 1483, she was betrothed to the Dauphin of France, later King Charles VIII of France, bringing with her a dowry of Franche-Comté and Artois, and was transferred to the guardianship of King Louis XI of France (see Treaty of Arras (1482)). After Charles renounced the treaty and married Anne of Brittany, Margaret was returned to her father in 1493.

In 1497, she was married to Juan, Prince of Asturias, Infante of Spain (1478–1497), the son and heir of King Ferdinand II of Aragon and Queen Isabella I of Castile, but he died after only six months. Juan left her pregnant, but she later gave birth to a stillborn child.

In 1501, she married Philibert II, Duke of Savoy (1480–1504), who died three years later. This marriage had been childless as well. She was appointed for the first time as governor of the Habsburg Netherlands (1507–1515) and guardian of her young nephew Charles (the future Charles V, Holy Roman Emperor).